Reduced cord blood immune effector-cell responsiveness mediated by CD4+ cells induced in utero as a consequence of placental Plasmodium falciparum infection.

@article{Brustoski2006ReducedCB,
  title={Reduced cord blood immune effector-cell responsiveness mediated by CD4+ cells induced in utero as a consequence of placental Plasmodium falciparum infection.},
  author={Kim Brustoski and Ulrike Moller and Martin Kramer and Franca C. Hartgers and Peter Gottfried Kremsner and Urszula Krzych and Adrian J F Luty},
  journal={The Journal of infectious diseases},
  year={2006},
  volume={193 1},
  pages={146-54}
}
To determine mechanisms of neonatal parasite antigen (Ag)-specific immune suppression associated with placental Plasmodium falciparum infection, we isolated cord blood mononuclear cells (CBMCs) from Gabonese neonates born to mothers with differing histories of P. falciparum infection and performed ex vivo and in vitro studies to evaluate immune regulatory activity. We found increased ex vivo percentages of CD4(+)CD25(hi) and CD4(+)CD25(+)CTLA-4(+) cells and increased interleukin (IL)-10… CONTINUE READING

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IFN-g and IL-10 mediate parasite-specific immune responses of cord blood cells induced by pregnancy-associated Plasmodium falciparum malaria

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CD 4 + CD 25 + - derived T regulatory cell lines express FoxP 3 protein and manifest potent suppressor function

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