Reduced content of lysyl-phosphatidylglycerol in the cytoplasmic membrane affects susceptibility to moenomycin, as well as vancomycin, gentamicin, and antimicrobial peptides, in Staphylococcus aureus.

@article{Nishi2004ReducedCO,
  title={Reduced content of lysyl-phosphatidylglycerol in the cytoplasmic membrane affects susceptibility to moenomycin, as well as vancomycin, gentamicin, and antimicrobial peptides, in Staphylococcus aureus.},
  author={Hiromi Nishi and Hitoshi Komatsuzawa and Tamaki Fujiwara and Nadine G. McCallum and Motoyuki Sugai},
  journal={Antimicrobial agents and chemotherapy},
  year={2004},
  volume={48 12},
  pages={4800-7}
}
An association between moenomycin resistance and vancomycin intermediate resistance in Staphylococcus aureus was demonstrated previously. Thus, to elucidate the mechanism of vancomycin intermediate resistance, we searched for factors contributing to moenomycin resistance. Random Tn551 insertional mutagenesis of methicillin-resistant S. aureus strain COL yielded three mutants with decreased susceptibilities to moenomycin. Correspondingly, these mutants also exhibited slightly decreased… CONTINUE READING

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