Reduced connexin 43 expression and its effect on the development of vascular lesions in retinas of diabetic mice.

@article{Bobbie2010ReducedC4,
  title={Reduced connexin 43 expression and its effect on the development of vascular lesions in retinas of diabetic mice.},
  author={Michael W Bobbie and Sumon Roy and Kyle M. Trudeau and Stephanie J. Munger and Alexander M. Simon and Sayon Roy},
  journal={Investigative ophthalmology & visual science},
  year={2010},
  volume={51 7},
  pages={3758-63}
}
PURPOSE. To examine whether diabetes-induced connexin 43 downregulation promotes retinal vascular lesions characteristic of diabetic retinopathy (DR). METHODS. Two animal models, streptozotocin-induced diabetic mice and Cx43 heterozygous knockout (Cx43(+/-)) mice, were studied to directly assess whether diabetes reduces the expression of retinal Cx43, which, in turn, contributes to retinal vascular cell loss by apoptosis. Retinal Cx43 protein levels were assessed in nondiabetic control mice… CONTINUE READING