Reduced concentrations of serum enhance the antiproliferative activity of retinoid-related molecules and accelerate the onset of apoptosis.

Retinoid-related molecules (RRMs) that are selective agonists for the retinoic acid receptor-gamma and one retinoid antagonist are potent inducers of apoptosis in various cancer cell lines. This cell-killing activity makes them promising candidates for their use as anticancer drugs. We have observed that reducing the amount of serum in the cell culture… CONTINUE READING