Reduced cerebrospinal fluid ethanolamine concentration in major depressive disorder

  title={Reduced cerebrospinal fluid ethanolamine concentration in major depressive disorder},
  author={Shintaro Ogawa and Kotaro Hattori and Daimei Sasayama and Yuki Yokota and Ryo Matsumura and Junko Matsuo and Miho Ota and Hiroaki Hori and Toshiya Teraishi and Sumiko Yoshida and Takamasa Noda and Yoshiaki Ohashi and Hajime Sato and Teruhiko Higuchi and Nobutaka Motohashi and Hiroshi Kunugi},
  booktitle={Scientific reports},
Amino acids play key roles in the function of the central nervous system, and their alterations are implicated in psychiatric disorders. In the search for a biomarker for major depressive disorder (MDD), we used high-performance liquid chromatography to measure amino acids and related molecules in the cerebrospinal fluid (CSF) of 52 patients with MDD (42 depressed and 10 remitted; DSM-IV) and 54 matched controls. Significant differences were found in four amino acid concentrations between the… CONTINUE READING
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