Reduced cerebral glucose metabolism in asymptomatic subjects at risk for Huntington's disease.

@article{Mazziotta1987ReducedCG,
  title={Reduced cerebral glucose metabolism in asymptomatic subjects at risk for Huntington's disease.},
  author={John C. Mazziotta and Michael E. Phelps and Jennifer Pahl and Shih-Che Huang and Lewis Baxter and Walter H. Riege and J. M. Hoffman and David E. Kuhl and Andy B. Lanto and J A Wapenski},
  journal={The New England journal of medicine},
  year={1987},
  volume={316 7},
  pages={357-62}
}
Symptomatic patients with Huntington's disease may have reduced glucose metabolism in the caudate nuclei. We used positron emission tomography and [18F]fluorodeoxyglucose to study cerebral glucose metabolism in 95 subjects: 58 clinically asymptomatic (chorea-free) subjects at risk for Huntington's disease, 10 symptomatic patients with the disease, and 27 controls. All the symptomatic patients had marked reductions in caudate glucose metabolism. Despite a normal structural appearance on computed… CONTINUE READING