Reduced cerebral blood flow with orthostasis precedes hypocapnic hyperpnea, sympathetic activation, and postural tachycardia syndrome.

@article{Pozzi2014ReducedCB,
  title={Reduced cerebral blood flow with orthostasis precedes hypocapnic hyperpnea, sympathetic activation, and postural tachycardia syndrome.},
  author={Andrew T Del Pozzi and Christopher E. Schwartz and Deepali Tewari and Marvin S. Medow and Julian M. Stewart},
  journal={Hypertension},
  year={2014},
  volume={63 6},
  pages={1302-8}
}
Hyperventilation and reduced cerebral blood flow velocity can occur in postural tachycardia syndrome (POTS). We studied orthostatically intolerant patients, with suspected POTS, with a chief complaint of upright dyspnea. On the basis of our observations of an immediate reduction of cerebral blood flow velocity with orthostasis, we hypothesize that the resulting ischemic hypoxia of the carotid body causes chemoreflex activation, hypocapnic hyperpnea, sympathetic activation, and increased heart… CONTINUE READING
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