Reduced caudate and nucleus accumbens response to rewards in unmedicated individuals with major depressive disorder.

@article{Pizzagalli2009ReducedCA,
  title={Reduced caudate and nucleus accumbens response to rewards in unmedicated individuals with major depressive disorder.},
  author={Diego A. Pizzagalli and Avram J. Holmes and Daniel G. Dillon and Elena Goetz and Jeffrey L. Birk and Ryan Bogdan and Darin D. Dougherty and Dan V. Iosifescu and Scott L. Rauch and Maurizio Fava},
  journal={The American journal of psychiatry},
  year={2009},
  volume={166 6},
  pages={
          702-10
        }
}
OBJECTIVE Major depressive disorder is characterized by impaired reward processing, possibly due to dysfunction in the basal ganglia. However, few neuroimaging studies of depression have distinguished between anticipatory and consummatory phases of reward processing. Using functional MRI (fMRI) and a task that dissociates anticipatory and consummatory phases of reward processing, the authors tested the hypothesis that individuals with major depression would show reduced reward-related responses… 

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