Reduced cardiac myofibrillar Mg-ATPase activity without changes in myosin isozymes in patients with end-stage heart failure

@article{Alousi1990ReducedCM,
  title={Reduced cardiac myofibrillar Mg-ATPase activity without changes in myosin isozymes in patients with end-stage heart failure},
  author={Adawia A. Alousi and Alison M. Grant and John R. Etzler and Barry R. Cofer and Joanna Van der Bel-Kahn and David Skene Melvin},
  journal={Molecular and Cellular Biochemistry},
  year={1990},
  volume={96},
  pages={79-88}
}
In this study we tested the hypothesis that reduced myofibrillar ATPase activities in end-stage heart failure are associated with a redistribution of myosin isozymes. Cardiac myofibrils were isolated from left ventricular free wall from normal human hearts and hearts at end-stage heart failure caused by coronary artery diseases, cardiomyopathy or immunological rejection. The hearts had been excised in preparation for a heart transplant. Myofibrillar Ca2−-dependent Mg-ATPase and myosin Ca−- and… CONTINUE READING
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