Reduced cardiac mass by nitrendipine is dissociated from systemic or regional haemodynamic changes in rats.

@article{Kobrin1984ReducedCM,
  title={Reduced cardiac mass by nitrendipine is dissociated from systemic or regional haemodynamic changes in rats.},
  author={Isaac Kobrin and Shogo Sesoko and Barbara L. Pegram and Edward David Frohlich},
  journal={Cardiovascular research},
  year={1984},
  volume={18 3},
  pages={158-62}
}
The effects of prolonged treatment (3 weeks) with nitrendipine (10 mg X kg-1 twice daily) on systemic and regional haemodynamics and cardiac mass were studied in SHR and WKY rats. Nitrendipine markedly decreased mean arterial pressure (26.0 +/- 0.4 vs 19.9 +/- 0.6 kPa, P less than 0.01) and total peripheral resistance (0.090 +/- 0.004 vs 0.066 +/- 0.004 U X kg-1, P less than 0.01) in SHR without significantly affecting cardiac output and heart rate, whereas in the WKY rats no significant… CONTINUE READING
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