Reduced carbohydrate availability enhances exercise-induced p53 signaling in human skeletal muscle: implications for mitochondrial biogenesis.

  title={Reduced carbohydrate availability enhances exercise-induced p53 signaling in human skeletal muscle: implications for mitochondrial biogenesis.},
  author={Jonathan D. Bartlett and Jari Louhelainen and Zafar Iqbal and Andrew J.R. Cochran and Martin J. Gibala and Warren Gregson and Graeme L. Close and Barry Drust and James P. Morton},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  volume={304 6},
The mechanisms that regulate the enhanced skeletal muscle oxidative capacity observed when training with reduced carbohydrate (CHO) availability are currently unknown. The aim of the present study was to test the hypothesis that reduced CHO availability enhances p53 signaling and expression of genes associated with regulation of mitochondrial biogenesis and substrate utilization in human skeletal muscle. In a repeated-measures design, muscle biopsies (vastus lateralis) were obtained from eight… 

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