Reduced capacity for the reactivation of glucocorticoids in rheumatoid arthritis synovial cells: possible role of the sympathetic nervous system?

@article{Schmidt2005ReducedCF,
  title={Reduced capacity for the reactivation of glucocorticoids in rheumatoid arthritis synovial cells: possible role of the sympathetic nervous system?},
  author={Martin Schmidt and Claudia Weidler and Heidrun Naumann and Sven Anders and Juergen Schoelmerich and Rainer H Straub},
  journal={Arthritis and rheumatism},
  year={2005},
  volume={52 6},
  pages={1711-20}
}
OBJECTIVE Cortisol, the biologically active glucocorticoid, is a major endogenous antiinflammatory factor in rheumatoid arthritis (RA). The aim of this study was to examine the local conversion of cortisol to biologically inactive cortisone and vice versa (the cortisol-cortisone shuttle) in RA and osteoarthritis (OA) patients. METHODS Thin-layer chromatography and phosphorimaging were used to examine the cortisol-cortisone shuttle in mixed synovial cells. Double immunohistochemistry was used… CONTINUE READING
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