Reduced c-Fos expression in medullary catecholaminergic neurons in rats 20 h after exposure to chronic intermittent hypoxia.

@article{Herr2013ReducedCE,
  title={Reduced c-Fos expression in medullary catecholaminergic neurons in rats 20 h after exposure to chronic intermittent hypoxia.},
  author={Kate Benincasa Herr and Georg M. Stettner and Leszek Kubin},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2013},
  volume={304 7},
  pages={R514-22}
}
Persons affected by obstructive sleep apnea (OSA) have increased arterial blood pressure and elevated activity in upper airway muscles. Many cardiorespiratory features of OSA have been reproduced in rodents subjected to chronic-intermittent hypoxia (CIH). We previously reported that, following exposure to CIH, rats have increased noradrenergic terminal density in brain stem sensory and motor nuclei and upregulated expression of the excitatory α(1)-adrenergic receptors in the hypoglossal motor… CONTINUE READING