Reduced brain volume and impaired memory in betaine homocysteine S-methyltransferase knockout mice.

Abstract

Using a mouse model, this study examined the impact of lack of betaine homocysteine S-methyltransferase (BHMT) on neurological function. Bhmt-/- mice maintained on a control diet had elevated concentrations of homocysteine, reduced total brain magnetic resonance imaging (MRI) volume, as well as impaired reference and short-term memories. The results of this… (More)
DOI: 10.1139/apnm-2017-0182

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