Reduced brain glucose with normal plasma glucose in salicylate poisoning.

@article{Thurston1970ReducedBG,
  title={Reduced brain glucose with normal plasma glucose in salicylate poisoning.},
  author={Jean Holowach Thurston and P G Pollock and Scott K. Warren and Elizabeth M. Jones},
  journal={The Journal of clinical investigation},
  year={1970},
  volume={49 11},
  pages={
          2139-45
        }
}
After the intraperitoneal injection into young mice of 700-800 mg/kg of salicylate, brain glucose fell to one-third or less of control values despite normal plasma glucose levels; brain lactate was nearly doubled and there were small decreases in phosphocreatine (18%) and in glycogen (17%). ATP, pyruvate, alpha-ketoglutarate, and glutamate were unchanged. In liver, glycogen was reduced 79% and lactate was five times higher than in control animals; glucose, glucose-6-phosphate, and ATP were… CONTINUE READING

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