Reduced brain UCP2 expression mediated by microRNA-503 contributes to increased stroke susceptibility in the high-salt fed stroke-prone spontaneously hypertensive rat

@inproceedings{Rubattu2017ReducedBU,
  title={Reduced brain UCP2 expression mediated by microRNA-503 contributes to increased stroke susceptibility in the high-salt fed stroke-prone spontaneously hypertensive rat},
  author={Speranza Rubattu and Rosita Stanzione and Franca Bianchi and Maria Cotugno and Maurizio Forte and Floriana Della Ragione and Salvatore Fioriniello and Maurizio D'Esposito and Simona Marchitti and Michele Madonna and Simona Baima and Giorgio Morelli and Sebastiano Sciarretta and Luigi Sironi and Paolo Gelosa and Massimo Volpe},
  booktitle={Cell death & disease},
  year={2017}
}
UCP2 maps nearby the lod score peak of STR1-stroke QTL in the SHRSP rat strain. We explored the potential contribution of UCP2 to the high-salt diet (JD)-dependent increased stroke susceptibility of SHRSP. Male SHRSP, SHRSR, two reciprocal SHRSR/SHRSP-STR1/QTL stroke congenic lines received JD for 4 weeks to detect brain UCP2 gene/protein modulation as compared with regular diet (RD). Brains were also analyzed for NF-κB protein expression, oxidative stress level and UCP2-targeted microRNAs… CONTINUE READING
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