Reduced brain GABA in primary insomnia: preliminary data from 4T proton magnetic resonance spectroscopy (1H-MRS).

@article{Winkelman2008ReducedBG,
  title={Reduced brain GABA in primary insomnia: preliminary data from 4T proton magnetic resonance spectroscopy (1H-MRS).},
  author={John W. Winkelman and Orfeu M. Buxton and J. Eric Jensen and Kathleen L Benson and Shawn P O'Connor and Wei Wang and Perry F. Renshaw},
  journal={Sleep},
  year={2008},
  volume={31 11},
  pages={1499-506}
}
STUDY OBJECTIVES Both basic and clinical data suggest a potential significant role for GABA in the etiology and maintenance of primary insomnia (PI). Proton magnetic resonance spectroscopy (1H-MRS) can non-invasively determine GABA levels in human brain. Our objective was to assess GABA levels in unmedicated individuals with PI, using 1H-MRS. DESIGN AND SETTING Matched-groups, cross-sectional study conducted at two university-based hospitals. PARTICIPANTS Sixteen non-medicated individuals… CONTINUE READING

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