Reduced bone mineral density is not associated with significantly reduced bone quality in men and women practicing long-term calorie restriction with adequate nutrition.

@article{Villareal2011ReducedBM,
  title={Reduced bone mineral density is not associated with significantly reduced bone quality in men and women practicing long-term calorie restriction with adequate nutrition.},
  author={Dennis T Villareal and John J. Kotyk and Reina C. Armamento-Villareal and Venkata Kenguva and Pamela Seaman and Allon Shahar and Michael J. Wald and Michael Kleerekoper and Edward Saltzman},
  journal={Aging cell},
  year={2011},
  volume={10 1},
  pages={96-102}
}
Calorie restriction (CR) reduces bone quantity but not bone quality in rodents. Nothing is known regarding the long-term effects of CR with adequate intake of vitamin and minerals on bone quantity and quality in middle-aged lean individuals. In this study, we evaluated body composition, bone mineral density (BMD), and serum markers of bone turnover and inflammation in 32 volunteers who had been eating a CR diet (approximately 35% less calories than controls) for an average of 6.8 ± 5.2 years… CONTINUE READING

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