Reduced binding of [18F]altanserin to serotonin type 2A receptors in aging: persistence of effect after partial volume correction

@article{Meltzer1998ReducedBO,
  title={Reduced binding of [18F]altanserin to serotonin type 2A receptors in aging: persistence of effect after partial volume correction},
  author={C. Meltzer and G. Smith and J. Price and C. Reynolds and Phil J. Greer and S. DeKosky},
  journal={Brain Research},
  year={1998},
  volume={813},
  pages={167-171}
}
The serotonin (5-HT) neurotransmitter system, which has a widespread distribution in the central nervous system, has been implicated in regulating mood and many human behaviors. There is evidence from postmortem human studies and limited information from prior in vivo studies to support a decline in 5-HT2A receptor density with aging. We examined nine elderly (ages 61-76) and nine young (ages 18-29) healthy individuals with positron emission tomography (PET) and [18F]altanserin, a ligand with… Expand
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References

SHOWING 1-10 OF 23 REFERENCES
Serotonin 5HT2 Receptor Imaging in the Human Brain Using Positron Emission Tomography and a New Radioligand, [18F]Altanserin: Results in Young Normal Controls
  • B. Sadzot, C. Lemaire, +8 authors G. Franck
  • Chemistry, Medicine
  • Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
  • 1995
  • 82
Serotonergic modulation of dopamine measured with [11C]raclopride and PET in normal human subjects.
  • 80
  • PDF
Fluorine-18-altanserin: a radioligand for the study of serotonin receptors with PET: radiolabeling and in vivo biologic behavior in rats.
  • 156
Brain 5-HT2 receptor binding sites in depressed suicide victims
  • 207
The detection of age-related decrease of dopamine D1, D2 and serotonin 5-HT2 receptors in living human brain
  • M. Iyo, T. Yamasaki
  • Medicine
  • Progress in Neuro-Psychopharmacology and Biological Psychiatry
  • 1993
  • 54
...
1
2
3
...