Reduced binding of [18F]altanserin to serotonin type 2A receptors in aging: persistence of effect after partial volume correction

  title={Reduced binding of [18F]altanserin to serotonin type 2A receptors in aging: persistence of effect after partial volume correction},
  author={C. Meltzer and G. Smith and J. Price and C. Reynolds and Phil J. Greer and S. DeKosky},
  journal={Brain Research},
The serotonin (5-HT) neurotransmitter system, which has a widespread distribution in the central nervous system, has been implicated in regulating mood and many human behaviors. There is evidence from postmortem human studies and limited information from prior in vivo studies to support a decline in 5-HT2A receptor density with aging. We examined nine elderly (ages 61-76) and nine young (ages 18-29) healthy individuals with positron emission tomography (PET) and [18F]altanserin, a ligand with… Expand
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