Reduced binding of [ 18 F ]altanserin to serotonin type 2A receptors in aging: persistence of effect after partial volume correction

  title={Reduced binding of [
 ]altanserin to serotonin type 2A receptors in aging: persistence of effect after partial volume correction},
  author={Carolyn C. Meltzer and Gwenn S. Smith and Julie C. Price and Charles F. Reynolds and Phil J. Greer and Steven T. DeKosky},
  journal={Brain Research},

Role and distribution of serotonin type 2A receptors in Alzheimer’s disease

  • Biology, Psychology
  • 2003
A generally decreased neocortical BP in AD was found with a significant regional reduction in the orbitofrontal, prefrontal, lateral frontal, cingulate, sensorimotor, parietal inferior, and occipital region, in line with previous postmortem, in vitro, and PET findings.

Age Effects on Serotonin Receptor 1B as Assessed by PET

Findings indicate that age is a relevant factor for 5-HT1B in the cortex of healthy adults via PET imaging, and a negative association with age was observed in all individual cortical regions.

Greater loss of 5-HT(2A) receptors in midlife than in late life.

5-HT(2A) receptor binding decreases dramatically in a variety of brain regions up through midlife, and there was less decrease in late life than in young healthy subjects.

PET imaging of serotonin type 2A receptors in late-life neuropsychiatric disorders.

It is suggested that the 5-HT2A receptor is differentially affected in late-life depression and Alzheimer's disease, a finding that has implications for the etiological basis of mood and cognitive features of neuropsychiatric disorders of late life.

A positron emission tomography study of 5-hydroxytryptamine-1A receptors in Alzheimer disease.

  • K. LanctôtD. Hussey S. Kapur
  • Biology, Medicine
    The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
  • 2007
Given the strategic role of these receptors, loss of right medial temporal 5-HT(1A) receptors might play an important role in AD symptomatology.



Serotonin 5HT2 Receptor Imaging in the Human Brain Using Positron Emission Tomography and a New Radioligand, [18F]Altanserin: Results in Young Normal Controls

  • B. SadzotC. Lemaire G. Franck
  • Biology, Chemistry
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
  • 1995
The results suggest that [18F]altanserin is selective for S2 receptors in vivo as it is in vitro, and indicate that it is suitable for imaging and quantifying S1 receptors with PET in humans.

Loss of brain 5-HT2 receptors in Alzheimer's disease. In vivo assessment with positron emission tomography and [18F]setoperone.

The results demonstrate that the loss in 5-HT2 receptor binding in the cerebral cortex of patients with Alzheimer's disease, long documented by post-mortem studies, can now be assessed in vivo using PET.

Serotonergic modulation of dopamine measured with [11C]raclopride and PET in normal human subjects.

The ability to measure serotonergic modulation of dopamine in vivo may have implications for the study of etiologic and therapeutic mechanisms in schizophrenia, major depressive disorder, obsessive-compulsive disorder, and substance abuse.

Fluorine-18-altanserin: a radioligand for the study of serotonin receptors with PET: radiolabeling and in vivo biologic behavior in rats.

This radiopharmaceutical appears to be more selective for S2 receptor sites than other ligands available today and allows the study of S2 receptors under in vivo conditions.

The detection of age-related decrease of dopamine D1, D2 and serotonin 5-HT2 receptors in living human brain

  • M. IyoT. Yamasaki
  • Biology, Psychology
    Progress in Neuro-Psychopharmacology and Biological Psychiatry
  • 1993