Reduced bicuculline response and GABAA agonist binding in aged rat hippocampus.

Abstract

Extracellular field recordings from CA1 pyramidal cells in the rat hippocampal slice preparation were used to examine the effects of age on gamma-aminobutyric acid (GABA)-mediated recurrent inhibition. The actions of bicuculline (1-100 microM), a GABAA antagonist, were assessed in slices from young (1-3 months) and aged (26 months) Fischer 344 rats. Pre… (More)

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@article{PostMunson1994ReducedBR, title={Reduced bicuculline response and GABAA agonist binding in aged rat hippocampus.}, author={Debra J. Post-Munson and J T Lum-Ragan and Cathy D. Mahle and Valentin K. Gribkoff}, journal={Neurobiology of aging}, year={1994}, volume={15 5}, pages={629-33} }