Reduced bicarbonate secretion mediates increased distal tubule acidification induced by dietary acid.


We examined the components of net HCO3 reabsorption (H+/HCO3 secretion) in in vivo perfused distal tubules of anesthetized rats to determine the mechanisms by which dietary acid increases acidification in this nephron segment. Animals eating a minimum electrolyte diet drank either 80 mM NH4Cl or 40 mM (NH4)2SO4 for 7-10 days and were compared with controls… (More)