Reduced beta-catenin and peroxisome proliferator-activated receptor-gamma expression levels are associated with colorectal cancer metastatic progression: correlation with tumor-associated macrophages, cyclooxygenase 2, and patient outcome.

@article{Pancione2009ReducedBA,
  title={Reduced beta-catenin and peroxisome proliferator-activated receptor-gamma expression levels are associated with colorectal cancer metastatic progression: correlation with tumor-associated macrophages, cyclooxygenase 2, and patient outcome.},
  author={Massimo Pancione and Nicola Rosario Forte and Lina Sabatino and Eugenio Tomaselli and Domenico Parente and Antonio Febbraro and Vittorio Colantuoni},
  journal={Human pathology},
  year={2009},
  volume={40 5},
  pages={
          714-25
        }
}
Recent studies have reported cross talk between beta-catenin, peroxisome proliferator-activated receptor-gamma, and cyclooxygenase 2 signaling pathways. We examined whether molecular changes of these pathways could be related to colorectal cancer metastatic progression. Seventy-two sporadic colorectal cancers and the distant nonneoplastic mucosa were analyzed for beta-catenin, peroxisome proliferator-activated receptor-gamma, cyclooxygenase 2, and nuclear factor kappaB levels by… CONTINUE READING
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