Reduced beta-amyloid response in lymphocytes of patients with Alzheimer's disease.

@article{Bondy1995ReducedBR,
  title={Reduced beta-amyloid response in lymphocytes of patients with Alzheimer's disease.},
  author={Brigitta Bondy and Marc Hofmann and Franz Mueller-Spahn and M Witzko and Christoph Hock},
  journal={Pharmacopsychiatry},
  year={1995},
  volume={28 4},
  pages={143-6}
}
The beta-amyloid peptide (beta A4) is a principal constituent of senile plaques and is thought to play a major role in the pathophysiology of Alzheimer's disease (AD). Although the mechanism of beta-A4 neurotoxicity is still a matter of debate, one of its effects might be a destabilization of cellular calcium homeostasis, thus promoting neuronal damage. The influence of the toxic fragment beta A25-35 on the mitogen-induced rise in the intracellular calcium concentration ([Ca2+]i) in lymphocytes… CONTINUE READING

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