Reduced beta 2-microglobulin mRNA levels in transgenic mice expressing a designed hammerhead ribozyme.

@article{Larsson1994ReducedB2,
  title={Reduced beta 2-microglobulin mRNA levels in transgenic mice expressing a designed hammerhead ribozyme.},
  author={Stella Larsson and Graham Hotchkiss and Michael And{\"a}ng and Thomas Nyholm and Jos{\'e} Antonio Inzunza and Irma Jansson and Lars Ahrlund-Richter},
  journal={Nucleic acids research},
  year={1994},
  volume={22 12},
  pages={2242-8}
}
We have generated three artificial hammerhead ribozymes, denoted 'Rz-b', 'Rz-c' and 'Rz-d', with different specificities for exon II of the mouse beta-2-microglobulin (beta 2M) mRNA. In this study we tested for ribozyme mediated reduction of beta 2M mRNA in a cell line and in transgenic mice. Transfections of either of the Rz-b, Rz-c or Rz-d plasmids into a… CONTINUE READING