Reduced benzodiazepine sensitivity in patients with premenstrual syndrome: a pilot study.

@article{Sundstrm1997ReducedBS,
  title={Reduced benzodiazepine sensitivity in patients with premenstrual syndrome: a pilot study.},
  author={I M Sundstr{\"o}m and D W Ashbrook and Torbj{\"o}rn Carl B{\"a}ckstr{\"o}m},
  journal={Psychoneuroendocrinology},
  year={1997},
  volume={22 1},
  pages={25-38}
}
Premenstrual syndrome (PMS) is characterized by cyclical changes in psychological and physical symptoms related to the formation of the corpus luteum and the fluctuations of gonadal hormones. Ovarian steroids have direct effects on neurotransmission, exemplified by the binding of certain metabolites of progesterone to the gamma-amino-butyric acid (GABAA) receptor where they exert a facilitating effect on inhibitory neurotransmission. There is also evidence for steroids with inverse-agonist… CONTINUE READING

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