Reduced benzodiazepine sensitivity in patients with panic disorder: comparison with patients with obsessive-compulsive disorder and normal subjects.

@article{RoyByrne1996ReducedBS,
  title={Reduced benzodiazepine sensitivity in patients with panic disorder: comparison with patients with obsessive-compulsive disorder and normal subjects.},
  author={Peter P. Roy-Byrne and D K Wingerson and Allen Radant and David J Greenblatt and Deborah S Cowley},
  journal={The American journal of psychiatry},
  year={1996},
  volume={153 11},
  pages={1444-9}
}
OBJECTIVE The authors sought to replicate their previous finding of reduced response to diazepam in patients with panic disorder, to test whether this effect was specific for panic disorder, and to determine whether this reduced response was merely an artifact of resistance to sedation from anxiety-related overarousal. METHOD The effects of four increasing intravenous doses of diazepam on saccadic eye movement velocity and accuracy (the latter being a saccadic variable that is unaffected by… CONTINUE READING