Reduced availability of brain amines during critical phases of postnatal development in a genetic mouse model of cognitive delay.

@article{Pascucci2008ReducedAO,
  title={Reduced availability of brain amines during critical phases of postnatal development in a genetic mouse model of cognitive delay.},
  author={Tiziana Pascucci and Diego Andolina and Rossella Ventura and Stefano Puglisi-Allegra and Simona Cabib},
  journal={Brain research},
  year={2008},
  volume={1217},
  pages={232-8}
}
Serotonin (5-HT), dopamine (DA) and noradrenaline (NE) play important roles in brain postnatal maturation. Therefore, deficits in brain availability of biogenic amines during critical developmental phases might underlie neurodevelopmental disturbances associated with cognitive impairment. To test this hypothesis we evaluated brain availability of 5-HT, DA and NE, of their immediate precursors 5-hydroxytryptophan and 3,4-dihydroxy-l-phenylalanine, and of large neutral amino acids phenylalanine… CONTINUE READING
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