Reduced aortic lesions and elevated high density lipoprotein levels in transgenic mice overexpressing mouse apolipoprotein A-IV.

@article{Cohen1997ReducedAL,
  title={Reduced aortic lesions and elevated high density lipoprotein levels in transgenic mice overexpressing mouse apolipoprotein A-IV.},
  author={Robert Donald Cohen and Lawrence W. Castellani and Jian-hua Qiao and Brian J. Van Lenten and Aldons J. Lusis and Karen Reue},
  journal={The Journal of clinical investigation},
  year={1997},
  volume={99 8},
  pages={1906-16}
}
Transgenic mouse lines carrying several copies of the mouse apo A-IV gene were produced. Lipoprotein composition and function, and aortic lesion development were examined. Apo A-IV levels in the plasma of transgenic mice were elevated threefold compared with nontransgenic littermates on a chow diet, and sixfold in mice fed an atherogenic diet. Plasma concentrations of total cholesterol, HDL cholesterol, triglycerides, and free fatty acids were similar in transgenic and control mice fed a chow… CONTINUE READING

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