Reduced anxiety and improved stress coping ability in mice lacking NPY-Y2 receptors.

@article{Tschenett2003ReducedAA,
  title={Reduced anxiety and improved stress coping ability in mice lacking NPY-Y2 receptors.},
  author={Alexandra Tschenett and Nicolas Singewald and Mirjana Carli and Claudia Balducci and Peter Salchner and Annamaria Vezzani and Herbert Herzog and G{\"u}nther Sperk},
  journal={The European journal of neuroscience},
  year={2003},
  volume={18 1},
  pages={143-8}
}
Neuropeptide Y (NPY) has been implicated in the pathophysiology of certain mood disorders, including depression and anxiety. It is, however, not known which of the five cloned NPY receptors mediate these functions. We investigated the effect of Y2 receptor deletion on anxiety and stress-related behaviours. In the elevated plus maze, Y2 knock out (Y2(-/-)) mice showed a 2.7-fold higher frequency of entering into, and spent 3.8 times more time within, the open arms compared to controls, while… CONTINUE READING