Reduced antioxidant enzyme activity in brains of mice transgenic for human presenilin-1 with single or multiple mutations

@inproceedings{Leutnera2006ReducedAE,
  title={Reduced antioxidant enzyme activity in brains of mice transgenic for human presenilin-1 with single or multiple mutations},
  author={Silke Leutnera and Katharina Schindowskia},
  year={2006}
}
  • Silke Leutnera, Katharina Schindowskia
  • Published 2006
Alzheimefs diseaserelated mutations in the ~resenilin-1 gene (PS11 are leadins to an elevated production of neurotoxic ß-amyloid 1-42 and may additionally enhance oxidatiie Stress. Here. we provide in viv0 evidence indicating that brains of transgenic mice expressing different human Alzheimer-linked PS1 mutations exhibit a reduced acüviiy of iwo antioxidant enzymes. For this purpose, mice transgenic for human PS1 and for single and multiple PS1 mutations were generated. Mice with multiple PS1… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 19 references

Progression of neuropathology in several transgenic mice expressing a single gene or two genes linked to familial Alzheimer's disease: APP, PS-1 or both proteins

S. Moussaoui, V. Blanchard, +5 authors A. Imperato
Soc. Neurosci., • 1999
View 4 Excerpts
Highly Influenced

Presenilins and Alzheimer's disease: biological functions and pathogenic

C. Czech, G. Tremp, L. Pradier
mechanisms, Prog. Neurobiol., • 2000

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