Reduced anterior cingulate cortex glutamatergic concentrations in childhood major depression.

  title={Reduced anterior cingulate cortex glutamatergic concentrations in childhood major depression.},
  author={Yousha Mirza and Jennifer Tang and Aileen Russell and Shailesh P. Banerjee and Rashmi P Bhandari and Jennifer Ivey and Michelle Rose and Gregory J. Moore and David R. Rosenberg},
  journal={Journal of the American Academy of Child and Adolescent Psychiatry},
  volume={43 3},
OBJECTIVE To examine in vivo glutamatergic neurochemical alterations in the anterior cingulate cortex of children with major depressive disorder (MDD). METHOD Single-voxel proton magnetic resonance spectroscopic (H-MRS) examinations of the anterior cingulate cortex were conducted in 13 psychotropic-naïve children and adolescents with MDD and 13 age- and sex-matched healthy children and adolescents. Ten of the 13 MDD patient-control pairs also had a H-MRS examination of occipital cortex… CONTINUE READING


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