Reduced anorexigenic efficacy of leptin, but not of the melanocortin receptor agonist melanotan-II, predicts diet-induced obesity in rats.

@article{Dijk2005ReducedAE,
  title={Reduced anorexigenic efficacy of leptin, but not of the melanocortin receptor agonist melanotan-II, predicts diet-induced obesity in rats.},
  author={G van Dijk and Koert de Vries and Csaba J. Nyakas and Bauke Buwalda and Tiziana Adage and Folkert Kuipers and Martien J. H. Kas and Roger A. H. Adan and Charles W Wilkinson and Todd E Thiele and Anton J. W. Scheurink},
  journal={Endocrinology},
  year={2005},
  volume={146 12},
  pages={
          5247-56
        }
}
Leptin gains access to the central nervous system where it influences activity of neuronal networks involved in ingestive behavior, neuroendocrine activity, and metabolism. In particular, the brain melanocortin (MC) system is important in leptin signaling and maintenance of energy balance. Although leptin or MC receptor insensitivity has been proposed to be associated with obesity, the present study compared central leptin and MC receptor stimulation on some of the above-mentioned parameters… CONTINUE READING

References

Publications referenced by this paper.
SHOWING 1-10 OF 60 REFERENCES

Feeding and temperature responses to intravenous leptin infusion are differential predictors of obesity in rats.

  • American journal of physiology. Regulatory, integrative and comparative physiology
  • 2004
VIEW 4 EXCERPTS

Central nervous system control of food intake

MW Schwartz, SC Woods, D JrPorte, RJ Seeley, DG. Baskin
  • Nature 2000;404:661–671
  • 2000
VIEW 6 EXCERPTS
HIGHLY INFLUENTIAL

Hyperphagia in rats produced by a mixture of fat and sugar

  • Physiology & Behavior
  • 1990
VIEW 3 EXCERPTS
HIGHLY INFLUENTIAL