Reduced angiotensinogen expression attenuates renal interstitial fibrosis in obstructive nephropathy in mice.

@article{Fern1999ReducedAE,
  title={Reduced angiotensinogen expression attenuates renal interstitial fibrosis in obstructive nephropathy in mice.},
  author={Robert J Fern and Christine M Yesko and Barbara A. Thornhill and Hyun Soo Kim and Oliver Smithies and Robert L. Chevalier},
  journal={The Journal of clinical investigation},
  year={1999},
  volume={103 1},
  pages={39-46}
}
A novel approach was employed to assess the contribution of the renin-angiotensin system (RAS) to obstructive nephropathy in neonatal mice having zero to four functional copies of the angiotensinogen gene (Agt). Two-day-old mice underwent unilateral ureteral obstruction (UUO) or sham operation; 28 days later, renal interstitial fibrosis and tubular atrophy were quantitated. In all Agt genotypes, UUO reduced ipsilateral renal mass and increased that of the opposite kidney. Renal interstitial… CONTINUE READING