Reduced amyloid deposition in mice overexpressing RTN3 is adversely affected by preformed dystrophic neurites.

@article{Shi2009ReducedAD,
  title={Reduced amyloid deposition in mice overexpressing RTN3 is adversely affected by preformed dystrophic neurites.},
  author={Qi Shi and Marguerite Prior and Wanxia He and Xiangying Tang and Xiangyou Hu and Riqiang Yan},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2009},
  volume={29 29},
  pages={9163-73}
}
Reticulon 3 (RTN3) was initially identified as a negative modulator of BACE1, an enzyme that cleaves amyloid precursor protein (APP) to release beta-amyloid peptide. Interestingly, RTN3 can also form aggregates after accumulation, and increased RTN3 aggregation correlates with the formation of RTN3 immunoreactive dystrophic neurites (RIDNs) in brains of Alzheimer's cases. Transgenic mice expressing RTN3 alone develop RIDNs in their hippocampus but not in their cortex. To determine the in vivo… CONTINUE READING

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