Reduced amygdala serotonin transporter binding in posttraumatic stress disorder.

@article{Murrough2011ReducedAS,
  title={Reduced amygdala serotonin transporter binding in posttraumatic stress disorder.},
  author={James W. Murrough and Yiyun Huang and Jian Hu and Shannan Henry and Wendol A. Williams and Jean-Dominique Gallezot and Christopher R. Bailey and John H. Krystal and Richard E. Carson and Alexander Neumeister},
  journal={Biological psychiatry},
  year={2011},
  volume={70 11},
  pages={1033-8}
}
BACKGROUND The amygdala is a key site where alterations in the regulation of the serotonin transporter (5-HTT) may alter stress response. Deficient 5-HTT function and abnormal amygdala activity have been hypothesized to contribute to the pathophysiology of posttraumatic stress disorder (PTSD), but no study has evaluated the 5-HTT in humans with PTSD. On the basis of translational models, we hypothesized that patients diagnosed with PTSD would exhibit reduced amygdala 5-HTT expression as… CONTINUE READING
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