Reduced alpha-defensin expression is associated with inflammation and not NOD2 mutation status in ileal Crohn's disease.

@article{Simms2008ReducedAE,
  title={Reduced alpha-defensin expression is associated with inflammation and not NOD2 mutation status in ileal Crohn's disease.},
  author={Lisa A. Simms and James D Doecke and M. D. Walsh and N Huang and Elizabeth V Fowler and Graham L Radford-Smith},
  journal={Gut},
  year={2008},
  volume={57 7},
  pages={903-10}
}
BACKGROUND AND AIMS Reduced ileal Paneth cell alpha-defensin expression has been reported to be associated with Crohn's disease, especially in patients carrying NOD2 mutations. The aim of this study was to independently assess whether NOD2, alpha-defensins and Crohn's disease are linked. METHODS Using quantitative real-time polymerase chain reaction (RT-PCR), we measured the mRNA expression levels of key Paneth cell antimicrobial peptides (DEFA5, DEFA6, LYZ, PLA2G2A), inflammatory cytokines… CONTINUE READING