Reduced alpha 1- and beta 2-adrenoceptor-mediated positive inotropic effects in human end-stage heart failure.

@article{Steinfath1992ReducedA1,
  title={Reduced alpha 1- and beta 2-adrenoceptor-mediated positive inotropic effects in human end-stage heart failure.},
  author={Markus Steinfath and W Danielsen and H von der Leyen and Ulrike Mende and Wilfried Meyer and John Neumann and Monika Nose and Terry Reich and W. Schmitz and Hasso Scholz},
  journal={British journal of pharmacology},
  year={1992},
  volume={105 2},
  pages={463-9}
}
1. alpha 1-Adrenoceptor (phenylephrine in the presence of propranolol) and beta 2-adrenoceptor (fenoterol)-mediated positive inotropic effects were investigated in human ventricular preparations isolated from five non-failing (prospective organ donors) and from eight explanted failing hearts with end-stage idiopathic dilative cardiomyopathy (NYHA IV). 2… CONTINUE READING