Reduced allele specific annexin A5 mRNA levels in placentas carrying the M2/ANXA5 allele.

@article{Markoff2010ReducedAS,
  title={Reduced allele specific annexin A5 mRNA levels in placentas carrying the M2/ANXA5 allele.},
  author={Arseni Markoff and Sebastian Gerdes and Stefan Feldner and Nadia Bogdanova and Volker Gerke and Elvira Grandone},
  journal={Placenta},
  year={2010},
  volume={31 10},
  pages={937-40}
}
We aimed to trace the allele specific expression of ANXA5 mRNA in placentas carrying the M2 haplotype, conferring higher recurrent pregnancy loss risk, in order to verify directly the role of M2 in the relevant organ. The M2 allele in heterozygous placentas results in an average of 42% reduced ANXA5 mRNA levels as compared to the normal allele. Protein levels in these samples show considerable variations, impossible for statistical interpretation. The M2 allele of ANXA5 can be linked to reduced… CONTINUE READING

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