Reduced adiposity and liver steatosis by stearoyl-CoA desaturase deficiency are independent of peroxisome proliferator-activated receptor-alpha.

@article{Miyazaki2004ReducedAA,
  title={Reduced adiposity and liver steatosis by stearoyl-CoA desaturase deficiency are independent of peroxisome proliferator-activated receptor-alpha.},
  author={Makoto Miyazaki and Agnieszka Dobrzyń and Harini Sampath and Seong-Ho Lee and Weng Chi Man and Kiki Chu and Jeffrey M. Peters and Frank J. Gonzalez and James M. Ntambi},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 33},
  pages={35017-24}
}
Stearoyl-CoA desaturase catalyzes the rate-limiting step in the biosynthesis of monounsaturated fatty acids, which are required for normal rates of synthesis of triglycerides, cholesterol esters, and phospholipids. Mice with a targeted disruption of the stearoyl-CoA desaturase 1 (SCD1) isoform are protected against diet and leptin deficiency-induced adiposity, have increased energy expenditure, and have up-regulated expression of hepatic genes encoding enzymes of fatty acid beta-oxidation… CONTINUE READING

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