Reduced adhesion of PBMNCs to endothelium in methylprednisolone-treated MS patients: preliminary results.

@article{Gelati1997ReducedAO,
  title={Reduced adhesion of PBMNCs to endothelium in methylprednisolone-treated MS patients: preliminary results.},
  author={Maurizio Gelati and Elena Corsini and Anna Dufour and Emilio Ciusani and Giorgio Massa and Simona Frigerio and C. Milanese and Angelo Nespolo and Andrea Salmaggi},
  journal={Acta neurologica Scandinavica},
  year={1997},
  volume={96 5},
  pages={283-92}
}
Methylprednisolone (MP) is a synthetic steroid commonly used in the treatment of multiple sclerosis (MS) relapses. It has a wide spectrum of activities on immune cells: it might also act by preventing mononuclear cell/endothelium adhesion. We studied adhesion phenomena between cultured human umbilical vein endothelial cells (HUVECs) and PBMNCs (CD45+, CD14+) from 6 MS patients treated in vivo with MP. We also studied fluctuations in CD11a and CD18 levels on lymphocytes and monocytes, as well as… CONTINUE READING