Reduced adaptation of a non-recombining neo-Y chromosome
@article{Bachtrog2002ReducedAO, title={Reduced adaptation of a non-recombining neo-Y chromosome}, author={Doris Bachtrog and Brian Charlesworth}, journal={Nature}, year={2002}, volume={416}, pages={323-326} }
Sex chromosomes are generally believed to have descended from a pair of homologous autosomes. Suppression of recombination between the ancestral sex chromosomes led to the genetic degeneration of the Y chromosome. In response, the X chromosome may become dosage-compensated. Most proposed mechanisms for the degeneration of Y chromosomes involve the rapid fixation of deleterious mutations on the Y. Alternatively, Y-chromosome degeneration might be a response to a slower rate of adaptive evolution…
160 Citations
Sex chromosome evolution: molecular aspects of Y-chromosome degeneration in Drosophila.
- BiologyGenome research
- 2005
Comparison of four large genomic regions located on the neo-sex chromosomes that contain a total of 12 homologous genes finds that both 5'- and 3'-flanking regions of genes and intron sequences are less constrained on the Nazi-era Y-chromosome compared to its neo-X homolog, which shows surprisingly uniform signs of degeneration.
Protein evolution and codon usage bias on the neo-sex chromosomes of Drosophila miranda.
- BiologyGenetics
- 2003
Comparisons of patterns of molecular evolution of 18 protein-coding genes located on the recombining neo-X and their homologs on the nonrecombined neo-Y chromosome suggest that there has been little or no selection maintaining codon bias in the D. miranda lineage.
Genomic degradation of a young Y chromosome in Drosophila miranda
- BiologyGenome Biology
- 2007
Patterns of genome evolution in D. miranda demonstrate that degeneration of a recently formed Y chromosome can proceed very rapidly, by both an accumulation of repetitive DNA and degenerating of protein-coding genes, support a random model of Y inactivation.
Ancient Male Recombination Shaped Genetic Diversity of Neo-Y Chromosome in Drosophila albomicans.
- BiologyMolecular biology and evolution
- 2016
This work elucidated the evolutionary scenario of the neo-Y chromosome of D. albomicans having high genetic diversity without assuming selective force, i.e., it originated from a single chromosomal fusion event, experienced meiotic recombination during the initial stage of evolution and diverged from neo-X chromosome by the suppression of recombination.
The Evolutionary Tempo of Sex Chromosome Degradation in Carica papaya
- BiologyJournal of Molecular Evolution
- 2015
A pattern of gene decay on the X-specific region of the Y chromosome may be explained by relaxed purifying selection and widespread genetic hitchhiking due to its pericentromeric location.
Adaptation shapes patterns of genome evolution on sexual and asexual chromosomes in Drosophila
- BiologyNature Genetics
- 2003
The limits to natural selection in an asexual genome are illustrated by comparing patterns of genome evolution in a 40-kb gene-rich region on homologous neo-sex chromosomes of Drosophila miranda.
Accelerated Adaptive Evolution on a Newly Formed X Chromosome
- BiologyPLoS biology
- 2009
Newly formed X chromosomes are not passive players in the evolutionary process of sex chromosome differentiation, but respond adaptively to both their sex-biased transmission and to Y chromosome degeneration, possibly through demasculinization of their gene content and the evolution of dosage compensation.
Sequence differentiation associated with an inversion on the neo-X chromosome of Drosophila americana.
- BiologyGenetics
- 2003
A nucleotide site defining a common haplotype in bib is shown to be associated with a paracentric inversion on the neo-X chromosome, which is consistent with the inversion acting as a recombination modifier that suppresses exchange between these neo-sex chromosomes, as predicted by models of sex chromosome evolution.
Neo-sex chromosomes in the black muntjac recapitulate incipient evolution of mammalian sex chromosomes
- BiologyGenome Biology
- 2007
It is reported for the first time that regulatory mutations were probably able to accelerate the degeneration process of Y and contribute to further evolution of dosage compensation and complex patterns of expression divergence between neo-Y and neo-X alleles.
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