Reduced activity of double-strand break repair genes in prostate cancer patients with late normal tissue radiation toxicity.

@article{Oorschot2014ReducedAO,
  title={Reduced activity of double-strand break repair genes in prostate cancer patients with late normal tissue radiation toxicity.},
  author={Bregje van Oorschot and Suzanne E Hovingh and Perry D. Moerland and Jan Paul Medema and Lukas J. A. Stalpers and Harry Vrieling and Nicolaas A P Franken},
  journal={International journal of radiation oncology, biology, physics},
  year={2014},
  volume={88 3},
  pages={664-70}
}
PURPOSE To investigate clinical parameters and DNA damage response as possible risk factors for radiation toxicity in the setting of prostate cancer. METHODS AND MATERIALS Clinical parameters of 61 prostate cancer patients, 34 with (overresponding, OR) and 27 without (non-responding, NR) severe late radiation toxicity were assembled. In addition, for a matched subset the DNA damage repair kinetics (γ-H2AX assay) and expression profiles of DNA repair genes were determined in ex vivo irradiated… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 10 extracted citations

Similar Papers

Loading similar papers…