Reduced activation of inflammatory responses in host cells by mouse-adapted Helicobacter pylory isolates.

@article{Philpott2002ReducedAO,
  title={Reduced activation of inflammatory responses in host cells by mouse-adapted Helicobacter pylory isolates.},
  author={Dana J Philpott and Djilali Belaid and Pascale Troubadour and Jean-Michel Thiberge and Jacques Tankovic and Agn{\'e}s Labigne and Richard L Ferrero},
  journal={Cellular microbiology},
  year={2002},
  volume={4 5},
  pages={
          285-96
        }
}
  • Dana J Philpott, Djilali Belaid, +4 authors Richard L Ferrero
  • Published in Cellular microbiology 2002
  • Biology, Medicine
  • Helicobacter pylori strains that harbour the Cag pathogenicity island (Cag PAI) induce interleukin (IL)-8 secretion in gastric epithelial cells, via the activation of NF- kappa B, and are associated with severe inflammation in humans. To investigate the influence of Cag PAI-mediated inflammatory responses on H. pylori adaptation to mice, a selection of H. pylori clinical isolates (n = 12) was cag PAI genotyped and tested in co-culture assays with AGS gastric epithelial cells, and in mouse… CONTINUE READING

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