Reduced activation and increased inactivation of thyroid hormone in tissues of critically ill patients.

@article{Peeters2003ReducedAA,
  title={Reduced activation and increased inactivation of thyroid hormone in tissues of critically ill patients.},
  author={R. Peeters and P. Wouters and E. Kaptein and H. van Toor and T. Visser and G. Van den Berghe},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2003},
  volume={88 7},
  pages={
          3202-11
        }
}
Critical illness is often associated with reduced TSH and thyroid hormone secretion as well as marked changes in peripheral thyroid hormone metabolism, resulting in low serum T(3) and high rT(3) levels. To study the mechanism(s) of the latter changes, we determined serum thyroid hormone levels and the expression of the type 1, 2, and 3 iodothyronine deiodinases (D1, D2, and D3) in liver and skeletal muscle from deceased intensive care patients. To study mechanisms underlying these changes, 65… Expand
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