Reduced ability of newborns to produce CCL3 is associated with increased susceptibility to perinatal human immunodeficiency virus 1 transmission.

@article{MeddowsTaylor2006ReducedAO,
  title={Reduced ability of newborns to produce CCL3 is associated with increased susceptibility to perinatal human immunodeficiency virus 1 transmission.},
  author={Stephen Meddows-Taylor and Samantha L. Donninger and Maria Paximadis and Diana Schramm and Fiona S. Anthony and Glenda Elisabeth Gray and Louise Kuhn and Caroline T Tiemessen},
  journal={The Journal of general virology},
  year={2006},
  volume={87 Pt 7},
  pages={2055-65}
}
The role of CC chemokines in protection against mother-to-child human immunodeficiency virus type 1 (HIV-1) transmission is not well understood. It was observed that mitogen-induced production of CCL3 and CCL4 by cord-blood mononuclear cells was increased among infants born to HIV-positive compared with HIV-negative mothers, and that a deficiency in production of CCL3 was associated with increased susceptibility to intrapartum HIV-1 infection. CCL3-L1 gene copy number was associated with CCL3… CONTINUE READING
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