Reduced ability of neonatal and early-life bone marrow stromal cells to support plasmablast survival.

@article{Pihlgren2006ReducedAO,
  title={Reduced ability of neonatal and early-life bone marrow stromal cells to support plasmablast survival.},
  author={Maria Pihlgren and Mathieu Friedli and Chantal Tougne and A Rochat and P. -H. Lambert and C. -A. Siegrist},
  journal={Journal of immunology},
  year={2006},
  volume={176 1},
  pages={165-72}
}
In human infants (<1 year), circulating IgG Abs elicited in response to most T-dependent Ags rapidly decline and return to baseline within a few months after immunization for yet-unknown reasons. In mice immunized between 1 and 4 wk of age, a limited establishment of the bone marrow (BM) pool of long-lived plasma cells is observed. In this study, we show that tetanus toxoid (TT)-specific plasmablasts generated in the spleen are efficiently attracted in vitro and in vivo toward early-life BM… CONTINUE READING

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