Reduced ability of hypothalamic and pituitary extracts from old mice to stimulate thymulin secretion in vitro.

@article{Goya1995ReducedAO,
  title={Reduced ability of hypothalamic and pituitary extracts from old mice to stimulate thymulin secretion in vitro.},
  author={Rodolfo G Goya and M C Gagnerault and Yolanda E Sosa and Mireille Dardenne},
  journal={Mechanisms of ageing and development},
  year={1995},
  volume={83 3},
  pages={143-54}
}
There is substantial evidence that growth hormone (GH) is particularly important in the control of the age-related decline of thymus function. It was therefore of interest: (a) to assess the overall capacity of tissue extracts from mediobasal hypothalamus (MBH), anterior pituitary (AP) and testis, obtained from young (3 months, Yc), middle-aged (13 months, MAc) and old (18 months, Oc) intact C57BL/6 mice to stimulate in vitro the release of thymulin, a Zn-bound immunoregulatory thymic peptide… CONTINUE READING