Reduced Treponema pallidum-Specific Opsonic Antibody Activity in HIV-Infected Patients With Syphilis.

@article{Marra2016ReducedTP,
  title={Reduced Treponema pallidum-Specific Opsonic Antibody Activity in HIV-Infected Patients With Syphilis.},
  author={Christina M. Marra and Lauren C. Tantalo and Sharon K. Sahi and Shelia B. Dunaway and Sheila A Lukehart},
  journal={The Journal of infectious diseases},
  year={2016},
  volume={213 8},
  pages={
          1348-54
        }
}
BACKGROUND Human immunodeficiency virus (HIV)-infected individuals may have poorer serological responses to syphilis treatment and may be more likely to experience neurosyphilis. Treponema pallidum is cleared from sites of infection by opsonization, ingestion, and killing by macrophages. METHODS Serum samples from 235 individuals with syphilis were tested for T. pallidum-specific opsonic activity. Blood T. pallidum concentrations were determined by real-time polymerase chain reaction… CONTINUE READING
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