Reduced Th1, but not Th2, cytokine production by lymphocytes after in vivo exposure of healthy subjects to endotoxin.

@article{Lauw2000ReducedTB,
  title={Reduced Th1, but not Th2, cytokine production by lymphocytes after in vivo exposure of healthy subjects to endotoxin.},
  author={Fanny N. Lauw and Tessa ten Hove and Pascal EP Dekkers and Evert de Jonge and Sander J.H. van Deventer and Tom van der Poll},
  journal={Infection and immunity},
  year={2000},
  volume={68 3},
  pages={1014-8}
}
Endotoxin (lipopolysaccharide [LPS]) tolerance is characterized by a reduced capacity of monocytes to produce proinflammatory cytokines upon restimulation in vitro. To determine whether LPS exposure induces a change in lymphocyte cytokine production and whether this results in a shift in the T-helper 1 (Th1)/Th2 balance, whole blood obtained from seven healthy subjects before and after an intravenous injection of LPS (4 ng/kg) was stimulated in vitro with the T-cell stimulus anti-CD3/CD28 or… CONTINUE READING